WP1: Development of four conceptually different NPBT
DNA-Free Genome Editing: Past, Present and Future
FRONTIERS – Open access publisher and open science platform
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Authors: Menz J, Modrzejewski D, Hartung F, Wilhelm R and Sprink T.
Development of 4 conceptually different NPBTs in C. intybus
CINECA IRIS – Institutional Research Information System
- Authors: Salvagnin, U., Malnoy, M.,, Martens, S., Hakkert, H., Van der Meer, I., Sevenier, R., Bundock, P. and de Both, M.
Metabolic engineering in chicory by CRISPR/CAS9 editing
XI International Agriculture Symposium « AGROSYM 2020 »
- Authors: Milica Bogdanović, Slađana Todorović, Katarina Ćuković, Milan Dragićević, Jules Beekwilder, Katarina Cankar, and Ana Simonović.
SCOPE enables type III CRISPR-Cas diagnostics using flexible targeting and stringent CARF ribonuclease activation
Nature Communications
- Authors: Jurre A. Steens, Yifan Zhu, David W. Taylor, Jack P. K. Bravo, Stijn H. P. Prinsen, Cor D. Schoen, Bart J. F. Keijser, Michel Ossendrijver, L. Marije Hofstra, Stan J. J. Brouns, Akeo Shinkai, John van der Oost and Raymond H. J. Staals.
A comparison of three different delivery methods for achieving CRISPR/Cas9 mediated genome editing in Cichorium intybus L.
FRONTIERS – Open access publisher and open science platform
- Authors: Umberto Salvagnin, Katharina Unkel, Thorben Sprink, Paul Bundock, Robert Sevenier, Milica Bogdanović, Slađana Todorović, Katarina Cankar, Johanna Christina Hakkert, Elio Schijlen, Ronald Nieuwenhuis, Maria Hingsamer, Veronika Kulmer, Michael Kernitzkyi, Dirk Bosch, Stefan Martens and Mickael Malnoy.
WP2: Implementation of NPBT for dietary inulin
Inactivation of the germacrene A synthase genes by CRISPR/Cas9 eliminates the biosynthesis of sesquiterpene lactones in Cichorium intybus L.
Plant Biotechnology Journal – Open Access
- Authors: Katarina Cankar, Paul Bundock, Robert Sevenier, Suvi T. Häkkinen, Johanna Christina Hakkert, Jules Beekwilder, Ingrid M. van der Meer, Michiel de Both and Dirk Bosch.
WP3: Implementation of NPBT in chicory for bioactive terpenes
CRISPR/Cas9 targeted inactivation of the kauniolide synthase in chicory results in accumulation of costunolide and its conjugates in taproots
FRONTIERS – Open access publisher and open science platform
- Authors: Katarina Cankar, Johanna Christina Hakkert, Robert Sevenier, Eva Campo, Bert Schipper, Christina Papastolopoulou, Khabat Vahabi, Alain Tissier, Paul Bundock and Dirk Bosch.
Lactucin Synthase Inactivation Boosts the Accumulation of Anti-inflammatory 8-Deoxylactucin and Its Derivatives in Chicory (Cichorium intybus L.)
ACS Publications – Most Trusted. Most Cited. Most Read.
- Authors: Katarina Cankar, Johanna Christina Hakkert, Robert Sevenier, Christina Papastolopoulou, Bert Schipper, João P. Baixinho, Naiara Fernández, Melanie S. Matos, Ana Teresa Serra, Claudia Nunes Santos, Khabat Vahabi, Alain Tissier, Paul Bundock and Dirk Bosch.
WP4: Technical -and risk- and regulatory assessment of NPBTs
Indigenous Perspectives on Gene Editing in Aotearoa New Zealand
FRONTIERS – Open access publisher and open science platform
- Authors: Maui Hudson, Aroha Te Pareake Mead, David Chagné, Nick Roskruge, Sandy Morrison, Phillip L. Wilcox and Andrew C. Allan
Genome Edited Crops Touch the Market: A View on the Global Development and Regulatory Environment
FRONTIERS – Open access publisher and open science platform
- Authors: Menz J, Modrzejewski D, Hartung F, Wilhelm R and Sprink T
WP5: Socio-economic and environmental impacts on the whole value chain
Filter methods for MRIO tables: An Evaluation
Taylor & Francis – Online
- Authors: Markus Simbürger.
Environmental and socio-economic impacts of new plant breeding technologies: A case study of root chicory for inulin production
FRONTIERS – Open access publisher and open science platform
- Authors: Maria Hingsamer, Veronika Kulmer, Matthew de Roode and Michael Kernitzkyi.
WP6: Stakeholder engagement
Towards social acceptability of genome-edited plants in industrialised countries? Emerging evidence from Europe, United States, Canada, Australia, New Zealand, and Japan
FRONTIERS – Open access publisher and open science platform
- Authors: Armin Spök, Thorben Sprink, Andrew C. Allan, Tomiko Yamaguchi and Christian Dayé
Social Acceptability of Cisgenic Plants: Public Perception, Consumer Preferences, and Legal Regulation
SPRINGER LINK – International Publishing
- Authors: Christian Dayé, Armin Spök, Andrew C. Allan, Tomiko Yamaguchi and Thorben Sprink
WP8: Commercial exploitation of chicory as a multipurpose crop
Assessing the Intestinal Permeability and Anti-Inflammatory Potential of Sesquiterpene Lactones from Chicory
MDPI – Publisher of open access journals
- Authors: Melanie S. Matos, José D. Anastácio, J. William Allwood, Diogo Carregosa, Daniela Marques, Julie Sungurtas, Gordon J. McDougall, Regina Menezes, Ana A. Matias, Derek Stewart and Cláudia Nunes dos Santos
Sesquiterpene Lactones: Promising Natural Compounds to Fight Inflammation
MDPI – Publisher of open access journals
- Authors: Melanie S. Matos, José D. Anastácio, and Cláudia Nunes dos Santos.
Supercritical CO2 Extraction as a Tool to Isolate Anti-Inflammatory Sesquiterpene Lactones from Cichorium intybus L. Roots
MDPI – Publisher of open access journals
- Authors: João P. Baixinho, José D. Anastácio, Viktoriya Ivasiv, Katarina Cankar, Dirk Bosch, Regina Menezes, Matthew de Roode, Cláudia Nunes dos Santos, Ana A. Matias and Naiara Fernández
Chicory Extracts and Sesquiterpene Lactones Show Potent Activity against Bacterial and Fungal Pathogens
MDPI – Publisher of open access journals
- Authors: Suvi T. Häkkinen, Marina Soković, Liisa Nohynek, Ana Ćirić, Marija Ivanov, Dejan Stojković, Irina Tsitko, Melanie Matos, João P. Baixinho, Viktoriya Ivasiv, Naiara Fernández, Claudia Nunes dos Santos, and Kirsi-Marja Oksman-Caldentey.
Targeting proteases involved in the viral replication of SARS-CoV-2 by sesquiterpene lactones from chicory (Cichorium intybus L.)
Royal Society of Chemistry – Food & Function
- Authors: María Ángeles Ávila-Gálvez, Carlos Rafael-Pita, Naiara Fernández, João Baixinho, José D. Anastácio, Katarina Cankar, Dirk Boschd and Cláudia Nunes dos Santos.
4th International Conference on Plant Biology (23rd SPPS Meeting)
Serbian Plant Physiology Society – Faculty of Biology, University of Belgrade
- Organizing Committee: Jelena Savić (President), Neda Aničić, Jelena Božunović, Milica Milutinović, Luka Petrović, Nina Devrnja, Tatjana Ćosić, Dragana Rajković, Živko Ćurčić, Marina Putnik-Delić, Dragica Milosavljević, Milorad Vujičić, Marija Ćosić and Miloš Ilić.
This project has received funding from the EU Horizon 2020 research & innovation programme under grant agreement N. 760891.