WP1: Development of four conceptually different NPBT

DNA-Free Genome Editing: Past, Present and Future

FRONTIERS – Open access publisher and open science platform

  • Authors: Menz J, Modrzejewski D, Hartung F, Wilhelm R and Sprink T.

Development of 4 conceptually different NPBTs in C. intybus

CINECA IRIS – Institutional Research Information System

  • Authors: Salvagnin, U., Malnoy, M.,, Martens, S., Hakkert, H., Van der Meer, I., Sevenier, R., Bundock, P. and de Both, M.

Metabolic engineering in chicory by CRISPR/CAS9 editing

XI International Agriculture Symposium “AGROSYM 2020”

  • Authors: Milica Bogdanović, Slađana Todorović, Katarina Ćuković, Milan Dragićević, Jules Beekwilder, Katarina Cankar, and Ana Simonović.

SCOPE enables type III CRISPR-Cas diagnostics using flexible targeting and stringent CARF ribonuclease activation

Nature Communications

  • Authors: Jurre A. Steens, Yifan Zhu, David W. Taylor, Jack P. K. Bravo, Stijn H. P. Prinsen, Cor D. Schoen, Bart J. F. Keijser, Michel Ossendrijver, L. Marije Hofstra, Stan J. J. Brouns, Akeo Shinkai, John van der Oost and Raymond H. J. Staals.

WP2: Implementation of NPBT for dietary inulin

Inactivation of the germacrene A synthase genes by CRISPR/Cas9 eliminates the biosynthesis of sesquiterpene lactones in Cichorium intybus L.

Plant Biotechnology Journal – Open Access

  • Authors: Katarina Cankar, Paul Bundock, Robert Sevenier, Suvi T. Häkkinen, Johanna Christina Hakkert, Jules Beekwilder, Ingrid M. van der Meer, Michiel de Both and Dirk Bosch.

WP3: Implementation of NPBT in chicory for bioactive terpenes

CRISPR/Cas9 targeted inactivation of the kauniolide synthase in chicory results in accumulation of costunolide and its conjugates in taproots

FRONTIERS – Open access publisher and open science platform

  • Authors: Katarina Cankar, Johanna Christina Hakkert, Robert Sevenier, Eva Campo, Bert Schipper, Christina Papastolopoulou, Khabat Vahabi, Alain Tissier, Paul Bundock and Dirk Bosch.

WP4: Technical -and risk- and regulatory assessment of NPBTs

Indigenous Perspectives on Gene Editing in Aotearoa New Zealand

FRONTIERS – Open access publisher and open science platform

  • Authors: Maui Hudson, Aroha Te Pareake Mead, David Chagné, Nick Roskruge, Sandy Morrison, Phillip L. Wilcox and Andrew C. Allan

Genome Edited Crops Touch the Market: A View on the Global Development and Regulatory Environment

FRONTIERS – Open access publisher and open science platform

  • Authors: Menz J, Modrzejewski D, Hartung F, Wilhelm R and Sprink T

WP5: Socio-economic and environmental impacts on the whole value chain

Filter methods for MRIO tables: An Evaluation

Taylor & Francis – Online

  • Authors: Markus Simbürger.

Environmental and socio-economic impacts of new plant breeding technologies: A case study of root chicory for inulin production

FRONTIERS – Open access publisher and open science platform

  • Authors: Maria Hingsamer, Veronika Kulmer, Matthew de Roode and Michael Kernitzkyi.

WP6: Stakeholder engagement

Towards social acceptability of genome-edited plants in industrialised countries? Emerging evidence from Europe, United States, Canada, Australia, New Zealand, and Japan

FRONTIERS – Open access publisher and open science platform

  • Authors: Armin Spök, Thorben Sprink, Andrew C. Allan, Tomiko Yamaguchi and Christian Dayé

WP8: Commercial exploitation of chicory as a multipurpose crop

Assessing the Intestinal Permeability and Anti-Inflammatory Potential of Sesquiterpene Lactones from Chicory

MDPI – Publisher of open access journals

  • Authors: Melanie S. Matos, José D. Anastácio, J. William Allwood, Diogo Carregosa, Daniela Marques, Julie Sungurtas, Gordon J. McDougall, Regina Menezes, Ana A. Matias, Derek Stewart and Cláudia Nunes dos Santos

Sesquiterpene Lactones: Promising Natural Compounds to Fight Inflammation

MDPI – Publisher of open access journals

  • Authors: Melanie S. Matos, José D. Anastácio, and Cláudia Nunes dos Santos.

Supercritical CO2 Extraction as a Tool to Isolate Anti-Inflammatory Sesquiterpene Lactones from Cichorium intybus L. Roots

MDPI – Publisher of open access journals

  • Authors: João P. Baixinho, José D. Anastácio, Viktoriya Ivasiv, Katarina Cankar, Dirk Bosch, Regina Menezes, Matthew de Roode, Cláudia Nunes dos Santos, Ana A. Matias and Naiara Fernández

Chicory Extracts and Sesquiterpene Lactones Show Potent Activity against Bacterial and Fungal Pathogens

MDPI – Publisher of open access journals

  • Authors: Suvi T. Häkkinen, Marina Soković, Liisa Nohynek, Ana Ćirić, Marija Ivanov, Dejan Stojković, Irina Tsitko, Melanie Matos, João P. Baixinho, Viktoriya Ivasiv, Naiara Fernández, Claudia Nunes dos Santos, and Kirsi-Marja Oksman-Caldentey.

Targeting proteases involved in the viral replication of SARS-CoV-2 by sesquiterpene lactones from chicory (Cichorium intybus L.)

Royal Society of Chemistry – Food & Function

  • Authors: María Ángeles Ávila-Gálvez, Carlos Rafael-Pita, Naiara Fernández, João Baixinho, José D. Anastácio, Katarina Cankar, Dirk Boschd and Cláudia Nunes dos Santos.
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