Regulatory Issues of NPBTs, What is the Process?

The process of New Plant Breeding Techniques (NPBTs), even though it’s been used for quite some time, is not widely accepted, especially among the general public. The CHIC project also focuses on assessing the technical, regulatory, and safety aspects of the four conceptional different new plant breeding methods used in the project, and the chicory plants and substances produced by those plants.

This part of the project is divided into five individual tasks:

Task 1 deals with the efficiency analysis of the four conceptional different NPBTs.

Task 2 focuses on the assessment of Off-targets in the genome-edited chicory plants, both tasks contribute to the technical assessment. During the reporting period a current guide RNA has been used to generate chicory plants which each of the conceptional different NPBTs, plants have been generated for all of them (stable, FLP-system, RNP, and Plasmid delivery). Additionally, also off-targets for the common guide RNA have been assessed and tested in first screens which need further validation.

Tasks 3 and 5 assess the regulatory aspects of NPBTs, due to the ECJ ruling the risk assessment of products derived by genome editing is currently the same as for GMOs in Europe but discussions are ongoing. Regulatory regimes are legislations all around the world that are being adapted to genome editing or novel legislations are being decreed. In many countries e.g. Russia and India, discussions are still ongoing and opinions are being collected in this task the first publication on this has been released recently.

Task 4 deals with the safety assessment of products derived by genome-edited chicory. During the current reporting period, terpene samples were tested for cytotoxicity using human intestinal epithelial cells. The work package has made good progress in the current reporting period which will be further improved in the next period.


Check out Work Package 4 video –

Work Package Leader

Dr. Thorben Sprink, WP4 Coordinator

Technical, Risk and Regulatory Assessment of NPBTs

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